How do I solve performance issues with OmniGraffle on my MBP

I am running OmniGraffle v5.3.6 on my 13" MBP (late 2011; Lion; 2,7Ghz; 4GB). I would NOT expect performance issues on this machine. For some reason it has significant delays when OmniGraffle is
running. It would stop for 2-10 seconds, then show the spinner for some seconds and then run normal again.

Any ideas what to do (except for stopping to use OmniGraffle)? ;-)